Pan-genome trees

Lars Snipen, David Wayne Ussery


We present the pan-genome tree as a tool for visualizing similarities and differences between closely related microbial genomes within a species or genus. Distance between genomes is computed as a weighted relative Manhattan distance based on gene family presence/absence. The weights can be chosen to with emphasis on groups of gene families conserved to various degrees inside the pan-genome. The software is available for free as an R-package.



pan-genome family trees

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Publication of Standards in Genomic Sciences has been transferred to a new publisher, BioMed Central on behalf of the Genomic Standards Consortium. All submissions to the journal should now be made directly through the BMC website for the journal at:


We would like to gratefully acknowledge the support of many members of the Genomic Standards Consortium, the broader genomic science community, and those who have indicated their willingness to serve as editors, reviewers and contributors.

SIGS was founded with grants from the Office of the Vice President for Research and Graduate Studies at Michigan State University, the Michigan State University Foundation, and the US Department of Energy Biological and Environmental Research DE-FG02-08ER64707. The journal became self-supporting on October 1, 2011.

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